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pentobarbital will lower the extent or outcome of pioglitazone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unidentified.pentobarbital will lessen the level or result of naloxegol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Usage of naloxegol with powerful CYP3A4 inducers just i